Annual report pursuant to Section 13 and 15(d)

Schedule of Stock-based Compensation Expense (Details)

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Schedule of Stock-based Compensation Expense (Details) - USD ($)
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]    
Total $ 3,408,015 $ 2,730,042
Research and Development Expense [Member]    
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]    
Total 809,839 863,069
General and Administrative Expense [Member]    
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]    
Total $ 2,598,176 $ 1,866,973